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Tyler McQuade
Dr. Tyler McQuade recently joined the Organic Division of the FSU Department of Chemistry and Biochemistry as Associate Professor. An Assistant Professor at Cornell University from 2001-2007, Professor McQuade graduated from the University of California - Irvine with a B.S. in Chemistry and a B.S. in Biology in 1992, and from the University of Wisconsin – Madison with a PhD in Chemistry in 1998. He received a number of awards, including the prestigious ACS graduate fellowship, as a graduate student working under the guidance of Professor Samuel Gellman. In addition, one of the surfactants for solubilizing membrane proteins described in his Ph.D. thesis has recently become commercially available. His post-doctorate research with Professor Timothy Swager at MIT was supported by an NIH Fellowship.
Dr. McQuade’s current research combines the organic, bioorganic and materials chemistry of his undergraduate, graduate and post-doc work to focus on creating multi-catalyst systems that will improve the quality and efficiency of chemical synthesis. His group’s long-term goal is to advance medical and biological research by creating multi-catalyst systems that provide access to new intermediates, yield more selective reactions, and allow the construction of many bonds in one vessel.
With a deep interest in sustainable chemistry (a more environmentally benign approach to science), Dr. McQuade and his group are working to make chemical synthesis - especially pharmaceutical production - less wasteful and expensive than it is now. His group’s multidisciplinary environment is yielding both polymers and small molecules that will provide the building blocks for next generation methodology and new tools for sustainable process chemistry. McQuade is currently a Dreyfus, 3M, Rohm and Haas, Beckman, and NYSTAR Young Investigator and was one of MIT Tech Review’s Top 100 Young Innovators in 2004.
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Our research
The McQuade Group’s overarching goal is a more complete understanding of chemical systems. We approach this goal by 1) creating new chemical systems that combine multiple catalysts to synthesize a desired compound in a single chemical operation and 2) creating small molecules designed to control natural biosynthetic systems (otherwise known as nature’s own multicatalyst systems).
These two approaches converge in our latest research focus: using multi-catalytic systems to design drugs that inhibit natural multicatalyst systems. One example of this synergy is our recent discovery of an antibiotic combination that provides excellent activity towards the bacteria which cause neonatal meningitis. Students who participate in McQuade Group research will not only learn to synthesize compounds but will also apply those compounds to important applications with the potential to benefit both public health and the chemical industry. Synthesis in the McQuade Group is dominated by the development of new catalytic reactions. In some cases, we combine two or more catalysts in a single reaction vessel to perform complex tandem reactions.
We also perform complex synthesis by using microfluidic devices. These outstanding tools - imported from chemical engineering - allow ultrafast mixing, rapid heat transfer, and enable multistep synthesis without purification. Experiment by experiment, we challenge ourselves to make every route we generate as green as possible. The push towards green chemistry drives many of today’s chemical innovations, and the McQuade Group is proud to be an active partner in that movement.
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Synthesis and characterization of cross-linked reverse micelles
J. Am. Chem. Soc. 2003, 125, 5351-5355
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Jung HM, Price KE, McQuade DT
A comparison of crystalline- and graft polymer-based chemosensors
J. Am. Chem. Soc. 2003, 125, 11154-11155
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Broadwater SJ, Hickey MK, McQuade DT
Baylis-Hillman mechanism: A new interpretation in aprotic solvents
Org. Lett 2005, 7, 147-150
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Price KE, Broadwater SJ, Jung HM, McQuade DT
A cross-linked reverse micelle-encapsulated palladium catalyst
Chem Comm 2005, 1714-1716
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Price KE, McQuade DT
A new interpretation of the Baylis-Hillman mechanism
J. Org. Chem. 2005, 70, 3980-3987
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Price KE, Broadwater SJ, Walker BJ, McQuade DT
Interfacial polymerization within a simplified microfluidic device: Capturing capsules
J. Am. Chem. Soc. 2005, 127, 10498-10499
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Elizabeth Quevedo, Jeremy Steinbacher, and D. Tyler McQuade
One-pot multi-step synthesis: a challenge spawning innovation
Org. Bio. Chem. 2005, 3, 2899-2906
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Broadwater SJ, Roth SL, Price KE, Kobaslija M, McQuade DT
Solving the clogging problem: Precipitate-forming reactions in flow
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION Volume: 45 Issue: 10 Pages: 1544-1548 Published: 2006
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Poe SL, Cummings MA, Haaf MR, McQuade DT
Investigating PdEnCat catalysis
JOURNAL OF ORGANIC CHEMISTRY Volume: 71 Issue: 5 Pages: 2131-2134 Published: MAR 3 2006
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Broadwater SJ, McQuade DT
2 \' Substituted sergeants influencing the deoxy soldiers in folded oligonucleotides
JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY Volume: 44 Issue: 10 Pages: 3271-3278 Published: MAY 15 2006
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Park JI, Roth SL, Price KE, Mcquade DT
Rapid self-assembly of core-shell organosilicon microcapsules within a microfluidic device
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY Volume: 128 Issue: 29 Pages: 9442-9447 Published: JUL 26 2006
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Steinbacher JL (Steinbacher, Jeremy L.), Moy RWY (Moy, Rebecca W. Y.), Price KE (Price, Kristin E.), Cummings MA (Cummings, Meredith A.), Roychowdhury C (Roychowdhury, Chandrani), Buffy JJ (Buffy, Jarrod J.), Olbricht WL (Olbricht, William L.), Haaf M (Haaf, Michael), McQuade DT (McQuade, D. Tyler)
Microencapsulated linear polymers: \
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY Volume: 128 Issue: 32 Pages: 10376-10377 Published: AUG 16 2006
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Price KE (Price, Kristin E.), Mason BP (Mason, Brian P.), Bogdan AR (Bogdan, Andrew R.), Broadwater SJ (Broadwater, Steven J.), Steinbacher JL (Steinbacher, Jeremy L.), McQuade DT (McQuade, D. Tyler)
